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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice

Fig. 6

Effects of riluzole on pathological changes of brain in 3xTg AD mice. (A-D, left) Pathological images of brain sections in AD_R (n = 4), AD_C (n = 4), C57_R (n = 3), and C57_C (n = 3) groups after 20 weeks of riluzole treatment. (A-D, right) The corresponding quantitative analysis of Aβ staining, Tau staining, GFAP staining, and Nissl staining in the hippocampal and/or cortical regions. Data were presented as mean ± SD. Statistical significance was denoted by *** p < 0.001, **** p < 0.0001, # p < 0.05, ## p < 0.01, ### p < 0.001, and #### p < 0.0001, relative to C57 (C57_R and C 57_C) mice; $ p < 0.05 and $$ p < 0.01, relative to AD (AD_R or AD_C) mice

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Alzheimer's Research & Therapy

ISSN: 1758-9193