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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model

Fig. 1

The Effects of probiotic supplementation on behavioral tasks. A Schematic of experimental design, detailing timeline from AAV infusion to tissue processing. B Distance traveled and time spent rearing in an open field maze test. C Number of marbles buried in a marble burying task. D Time spent in the closed arm and number of head dips over the edge in an elevated plus maze (EPM) test. E Percentage of sucrose solution consumption over a 24 h period. F Percentage of time spent in the novel arm in a Y-maze test. G Discrimination index in a spontaneous location recognition (SLR) task. H Discrimination index in an odor discrimination task. Ctrl: control. P/P: probiotic + prebiobiotic. N: GFP + Ctrl Diet: 6 F/5 M; GFP + P/P Diet: 6 F/6 M; htauE14 + Ctrl Diet: 6 F/8 M; htauE14 + P/P Diet: 6 F/4 M. *p < 0.05, **p < 0.01

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