Fig. 4
The effects of probiotic supplementation on peripheral and central inflammation. A Concentration of IL6 (mg/ml) from plasma at 12-months of age. N: GFP + Ctrl Diet: 4 F/6 M; GFP + P/P Diet: 4 F/6 M; htauE14 + Ctrl Diet: 8 F/2 M; htauE14 + P/P Diet: 6 F/4M. B Concentration of TNFa (mg/ml) from plasma at 12-months of age. N: GFP + Ctrl Diet: 6 F/7 M; GFP + P/P Diet: 6 F/6 M; htauE14 + Ctrl Diet: 9 F/2 M; htauE14 + P/P Diet: 7 F/5M. C Concentration of IL10 (mg/ml) from plasma at 12-months of age. N: GFP + Ctrl Diet: 5 F/3 M; GFP + P/P Diet: 5 F/6 M; htauE14 + Ctrl Diet: 6 F/2 M; htauE14 + P/P Diet: 5 F/4M. D Number of Iba1 cells per mm2 in the LC. N: GFP + Ctrl Diet: 6 F/4 M; GFP + P/P Diet: 5 F/4 M; htauE14 + Ctrl Diet: 4 F/4 M; htauE14 + P/P Diet: 3 F/3M. E Number of CD68 cells per mm2 in the LC. N: GFP + Ctrl Diet: 6 F/4 M; GFP + P/P Diet: 4 F/4 M; htauE14 + Ctrl Diet: 4 F/4 M; htauE14 + P/P Diet: 4 F/4M. F Number of GFAP cells per mm2 in the LC. N: GFP + Ctrl Diet: 3 F/3 M; GFP + P/P Diet: 5 F/4 M; htauE14 + Ctrl Diet: 3 F/3 M; htauE14 + P/P Diet: 3 F/3M. G Mean intensity of Albumin staining in the LC. N: GFP + Ctrl Diet: 4 F/4 M; GFP + P/P Diet: 4 F/4 M; htauE14 + Ctrl Diet: 4 F/4 M; htauE14 + P/P Diet: 5 F/4 M. Example images of Iba-1, CD68, GFAP, and Albumin, respectively, in the LC across all groups were shown in the lower panels. Scale bars: 50 μm. Arrows indicate positively stained cells. *p < 0.05, **p < 0.01