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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment

Fig. 2

Results from mediation analyses. One mediation analysis was conducted per cognitive test with three predictors (Braak stage, CERAD score, presence of Lewy body pathology), two mediators (posterior basal forebrain volume, hippocampus volume) and covariates for age, sex, years of education, time interval between MRI and autopsy, and site. 95% credible intervals of the parameter estimates were estimated. Credible intervals that don’t overlap with zero are marked in orange. Note that CERAD was included in the models, but is not displayed in the figure as none of the effects for CERAD was significant (see Supplementary Figures S2-4 for complete mediation results including all three mediators). c = total effect of pathology on cognition, c’= direct effect of pathology on cognition controlling for volume, a = effect of pathology on volume, b = effect of volume on cognition, a*b = indirect effect of pathology on cognition mediated via volume (= c-c’). CDR, clinical dementia rating; hippo vol, normalised hippocampus volume; Lewy, presence of Lewy body pathology; pBF vol, normalised posterior basal forebrain volume

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Alzheimer's Research & Therapy

ISSN: 1758-9193