Table 3 Effect of tau, amyloid, and Lewy body pathology on regional brain volumes
Model | P(M) | P(M|data) | BFM | BF10 | Error % | Evidence for H1/H0 |
|---|---|---|---|---|---|---|
Posterior basal forebrain volume | ||||||
Null model | 0.25 | 0.003 | 0.01 | 1.0 | ||
Lewy + Braak | 0.083 | 0.68 | 36.2 | 664.6 | 3.7 | Extreme for H1 |
Lewy + Braak + CERAD | 0.25 | 0.28 | 0.90 | 90.5 | 3.4 | Very strong for H1 |
Lewy + CERAD | 0.083 | 0.02 | 0.18 | 19.6 | 3.9 | Strong for H1 |
Lewy | 0.083 | 0.01 | 0.10 | 10.7 | 6.9 | Strong for H1 |
Braak | 0.083 | 0.006 | 0.05 | 5.8 | 2.3 | Moderate for H1 |
Braak + CERAD | 0.083 | 5.6*10− 4 | 0.005 | 0.55 | 3.1 | Weak for H0 |
CERAD | 0.083 | 4.6*10− 4 | 0.004 | 0.45 | 3.1 | Weak for H0 |
Anterior basal forebrain volume | ||||||
Null model | 0.25 | 0.64 | 4.3 | 1.0 | ||
CERAD | 0.083 | 0.22 | 4.5 | 1.03 | 3.7 | Weak for H1 |
Braak | 0.083 | 0.04 | 0.57 | 0.20 | 1.4 | Moderate for H0 |
CERAD + Lewy | 0.083 | 0.04 | 0.49 | 0.17 | 5.6 | Moderate for H0 |
Lewy | 0.083 | 0.03 | 0.37 | 0.13 | 2.2 | Moderate for H0 |
Braak + CERAD | 0.083 | 0.01 | 0.14 | 0.05 | 1.8 | Very strong for H0 |
Braak + Lewy | 0.083 | 0.009 | 0.11 | 0.04 | 7.5 | Very strong for H0 |
Braak + CERAD + Lewy | 0.25 | 0.007 | 0.03 | 0.01 | 2.5 | Very strong for H0 |
Hippocampus volume | ||||||
Null model | 0.25 | 4.8*10− 6 | 1.2*10− 5 | 1.0 | ||
Braak | 0.083 | 0.67 | 16.3 | 422,422 | Extreme for H1 | |
Braak + CERAD | 0.083 | 0.19 | 1.7 | 116,617 | Extreme for H1 | |
Braak + Lewy | 0.083 | 0.09 | 0.68 | 53,193 | Extreme for H1 | |
Braak + CERAD + Lewy | 0.25 | 0.06 | 0.14 | 11,497 | Extreme for H1 | |
CERAD | 0.083 | 9.0*10− 4 | 0.007 | 565.2 | Extreme for H1 | |
CERAD + Lewy | 0.083 | 9.6*10− 5 | 7.0*10− 4 | 60.2 | Very strong for H1 | |
Lewy | 0.083 | 4.8*10− 7 | 3.5*10− 6 | 0.30 | Moderate for H0 | |