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Table 4 Group comparison of cognition

From: Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment

 

Pure AD

Pure LBD

Mixed AD/ LBD

Overall group comparison

Pairwise comparisons

Pure AD

vs. pure LBD

Pure AD vs. mixed

Pure LBD vs. mixed

CDR SOB

10.9

(5.8)

9.1

(5.3)

11.5

(5.4)

BF10 = 0.59

-

-

-

MMSE

16.5

(7.5)

21.2

(4.5)

15.8

(6.3)

BF10 = 7.3

BF10 = 20.0

BF10 = 0.10

BF10 = 218.2

Boston Naming

16.1

(8.5)

24.8

(3.1)

16.8

(7.6)

BF10 = 421

BF10 = 2135

BF10 = 0.19

BF10 = 1444

Immediate recall

3.2

(3.9)

6.4

(5.6)

2.6

(3.1)

BF10 = 368

BF10 = 133

BF10 = 0.15

BF10 = 14,965

Delayed recall

2.1

(3.5)

4.9

(5.3)

1.6

(2.8)

BF10 = 88.5

BF10 = 65.5

BF10 = 0.15

BF10 = 2036

Digit span forw. – trials

6.2

(2.6)

7.1

(2.0)

6.2

(2.4)

BF10 = 0.25

-

-

-

Digit span forw. – length

5.4

(1.6)

5.8

(1.4)

5.3

(1.4)

BF10 = 0.15

-

-

-

Digit span backw. – trials

3.6

(2.1)

4.2

(1.3)

3.4

(2.0)

BF10 = 0.11

-

-

-

Digit span backw. – length

3.1

(1.5)

3.5

(0.7)

3.0

(1.4)

BF10 = 0.13

-

-

-

Animals

7.4

(5.2)

10.6

(2.9)

6.2

(2.4)

BF10 = 4.4

BF10 = 16.9

BF10 = 0.16

BF10 = 206

Vegetables

4.4

(3.8)

5.7

(2.3)

5.3

(1.4)

BF10 = 6.1

BF10 = 2.7

BF10 = 0.35

BF10 = 223

TMT B-TMT A

174.1

(67.0)

176.3

(56.8)

185.2

(52.2)

BF10 = 0.23

-

-

-

Digit Symbol Test

21.0

(13.6)

22.7

(11.8)

19.4

(12.3)

BF10 = 0.08

-

-

-

  1. Mean (standard deviation) and group comparison by Bayesian ANCOVAs including covariates for age, sex, years of education, and time between last clinical visit and autopsy. If the overall model indicated at least moderate evidence for a difference between groups (BF10 > 3), post-hoc pairwise comparisons were performed
  2. AD, Alzheimer’s disease; BF, basal forebrain; BF10, Bayes factor in favor of H1 over H0; CDR SOB, Clinical Dementia Rating sum of boxes; LBD, Lewy body disease; MMSE, Mini Mental State Examination; TMT, Trail Making Test