Fig. 3

RO7019009 lowers Aβ43 in heterozygous PS1 L166P KI MEF cells. A-C Ratios of secreted Aβ43 (A), Aβ42 (B) or Aβ42 + 43 (C) (% of the sum of measured Aβ (38 + 40 + 42 + 43)) from WT or KI MEF cells treated with the indicated GSM (GSM-1 and RO5254601 at 2.5 µM, RO-02 and RO7019009 at 500 nM and BPN-15606 at 360 nM, respectively) (n = 4–7). Aβ species were measured by species-specific Aβ ELISA (IBL). Data are shown together with the corresponding DMSO controls and are presented as mean + SEM. Dashed red lines highlight the corresponding ratio of the DMSO-vehicle treated WT control. Missing data points are due to Aβ levels below the detection limit of the assay. Statistical significance was tested using one-way ANOVA with Dunnet’s multiple comparison test. Groups with less than two data points were excluded from the analysis