Table 2 Univariate and multivariate analysis of CSF β-syn levels in sCJD and gCJD groups
Factors | No | β-syn median (pg/ml, IQR) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|
Test's statistic | p-value | B (95% CI) | t | p-value | ||||
Gender | Male | 85 | 2366 (990.00–4141.50) | 3736.0 | 0.697a | NA | NA | NA |
Female | 91 | 2191 (730.00–4332.00) | ||||||
Median age at onset (year) | < 50 | 20 | 1215.5 (600.25–2478.50) | 3.4 | 0.186b | NA | NA | NA |
50 ~ 70 | 130 | 2591 (994.25–4374.25) | ||||||
> 70 | 26 | 2014.5 (706.50–4801.25) | ||||||
WB CSF 14-3-3 | Negative | 59 | 1335 (537.00–2612.00) | 2031.5 | 0.000a | 1462.93 (792.59–2133.27) | 4.308 | 0.000 |
Positive | 116 | 2973.5 (1139.25–5523.25) | ||||||
EEG | Normal | 42 | 3137 (888.25–5589.00) | 972.5 | 0.905a | NA | NA | NA |
PSWC | 47 | 2755 (1217.00–5756.00) | ||||||
MRI | Normal | 29 | 2109 (497.00–3002.50) | 1666.5 | 0.087a | NA | NA | NA |
Abnormal | 144 | 2441.5 (992.25–4531.00) | ||||||
Myoclonus | No | 67 | 1538 (606.00–3098.00) | 2849.5 | 0.015a | 260.34 (−424.57–945.26) | 0.750 | 0.454 |
Yes | 109 | 2724 (1104.50–4939.50) | ||||||
Visual or cerebellar disturbance | No | 39 | 2498 (889.00–4158.00) | 2567.0 | 0.710a | NA | NA | NA |
Yes | 137 | 2166 (957.50–4228.50) | ||||||
Pyramidal or extrapyramidal dysfunction | No | 27 | 1989 (606.00–4078.00) | 1802.0 | 0.390a | NA | NA | NA |
Yes | 149 | 2385 (976.00–4245.00) | ||||||
Akinetic Mutism | No | 96 | 1949.5 (732.50–3123.50) | 2838.0 | 0.003a | 907.34 (244.77–1569.91) | 2.703 | 0.008 |
Yes | 80 | 2993 (1111.00–5719.50) | ||||||
Survival time (month) | < 3 | 16 | 1447 (909.50–2128.00) | 4.5 | 0.104b | NA | NA | NA |
3 ~ 5 | 38 | 2057 (1154.25–4771.00) | ||||||
> 5 | 12 | 3143.5 (977.25–5753.25) | ||||||