Table 3 Youden index cutoffs for the discrimination of prion disease from the other cohorts and the corresponding AUC, sensitivity, specificity, and positive likelihood ratio
Comparison | Youden index | AUC | Positive likelihood ratio | β-syn cut-off, pg/ml | Sensitivity (95% CI), % | Specificity (95% CI), % | |
|---|---|---|---|---|---|---|---|
AD + PD vs | sCJD | 0.578 | 0.764 | 2.965 | 337.0 | 87.21 (78.53–92.71) | 70.59 (46.87–86.72) |
T188K-gCJD | 0.703 | 0.849 | 4.983 | 842.5 | 87.93 (77.12–94.03) | 82.35 (58.97–93.81) | |
E200K-gCJD | 0.675 | 0.855 | 3.294 | 332.5 | 96.88 (84.26–99.84) | 70.59 (46.87–86.72) | |
P102L-GSS | 0.609 | 0.769 | 4.452 | 809.5 | 78.59 (52.41–92.43) | 82.35 (58.97–93.81) | |
D178N-FFI | 0.374 | 0.721 | 2.061 | 266.0 | 72.73 (55.78–84.93) | 64.71 (41.30–82.69) | |
VE + AE vs | sCJD | 0.295 | 0.577 | 1.465 | 271.5 | 93.02 (85.60–96.76) | 36.49 (26.44–47.87) |
T188K-gCJD | 0.445 | 0.707 | 2.221 | 1304.0 | 81.03 (69.15–89.07) | 63.51 (52.13–73.56) | |
E200K-gCJD | 0.421 | 0.701 | 2.073 | 1159.0 | 81.25 (64.69–91.11) | 60.81 (49.42–71.14) | |
P102L-GSS | 0.330 | 0.606 | 1.626 | 598.0 | 85.71 (60.06–97.46) | 47.03 (36.34–58.52) | |
D178N-FFI | 0.196 | 0.512 | 1.264 | 145.5 | 93.94 (80.39–98.92) | 25.68 (17.10–36.65) | |