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Table 3 Standardized eGFR β-Estimates for Plasma Alzheimer's Disease Biomarkers: Univariate and Multivariable Models

From: The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity

Biomarker

Model

β Estimate

95% CI (Lower)

95% CI (Upper)

p-value

Plasma Aβ42

Univariate

-0.29

-0.40

-0.18

9.92e-7

Plasma Aβ42

Adjusted (age + sex)

-0.54

-0.71

-0.38

5.86e-10

Plasma Aβ42

Adjusted (age + sex + Aβ-PET)

-0.51

-0.66

-0.35

3.11e-10

Plasma Aβ40

Univariate

-0.53

-0.63

-0.43

3.98e-21

Plasma Aβ40

Adjusted (age + sex)

-0.49

-0.64

-0.34

7.93e-10

Plasma Aβ40

Adjusted (age + sex + Aβ-PET)

-0.47

-0.62

-0.32

4.75e-9

Plasma Aβ42/40

Univariate

0.23

0.11

0.34

 < 0.001

Plasma Aβ42/40

Adjusted (age + sex)

-0.14

-0.30

0.03

0.100

Plasma Aβ42/40

Adjusted (age + sex + Aβ-PET)

-0.13

-0.28

0.02

0.097

Plasma p-tau181

Univariate

-0.24

-0.36

-0.12

5.91e-5

Plasma p-tau181

Adjusted (age + sex)

-0.13

-0.30

0.04

0.136

Plasma p-tau181

Adjusted (age + sex + Aβ-PET)

-0.12

-0.28

0.04

0.143

Plasma p-tau217

Univariate

-0.25

-0.38

-0.13

4.87e-5

Plasma p-tau217

Adjusted (age + sex)

-0.11

-0.28

0.06

0.216

Plasma p-tau217

Adjusted (age + sex + Aβ-PET)

-0.11

-0.25

0.03

0.113

Plasma p-tau231

Univariate

-0.16

-0.28

-0.05

0.007

Plasma p-tau231

Adjusted (age + sex)

-0.11

-0.28

0.07

0.232

Plasma p-tau231

Adjusted (age + sex + Aβ-PET)

-0.11

-0.28

0.05

0.183

Plasma NTA-tau

Univariate

-0.07

-0.19

0.05

0.242

Plasma NTA-tau

Adjusted (age + sex)

-0.14

-0.32

0.04

0.132

Plasma NTA-tau

Adjusted (age + sex + Aβ-PET)

-0.15

-0.32

0.02

0.085

Plasma NfL

Univariate

-0.49

-0.59

-0.38

1.21e-17

Plasma NfL

Adjusted (age + sex)

-0.40

-0.55

-0.24

8.64e-7

Plasma NfL

Adjusted (age + sex + Aβ-PET)

-0.38

-0.54

-0.23

1.55e-6

Plasma GfAP

Univariate

-0.41

-0.52

-0.30

1.66e-12

Plasma GfAP

Adjusted (age + sex)

-0.19

-0.35

-0.04

0.016

Plasma GfAP

Adjusted (age + sex + Aβ-PET)

-0.19

-0.33

-0.05

0.007

  1. This table presents the β-estimates, 95% confidence intervals (CI), and p-values for the association between standardized eGFR and various plasma AD biomarkers, including Aβ42, Aβ40, p-tau217, p-tau231, NfL, GFAP, and the Aβ42/Aβ40 ratio. The results are shown for three different models: univariate (no adjustments), adjusted for age and sex, and adjusted for age, sex, and Aβ-PET status. The p-values indicate the statistical significance of these associations, with values below 0.05 considered significant
  2. Abbreviations: eGFR estimated glomerular filtration rate, Aβ42 amyloid-beta 42, Aβ40 amyloid-beta 40, p-tau181 phosphorylated tau at threonine 181, p-tau217 phosphorylated tau at threonine 217, p-tau231 phosphorylated tau at threonine 231, NTA-tau N-terminal containing tau fragments, NFL Neurofilament light chain, GFAP Glial fibrillary acidic protein, Aβ-PET Amyloid-beta positron emission tomography
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Alzheimer's Research & Therapy

ISSN: 1758-9193