Table 1 Nonsignificant CSF biomarker based on non elevated CSF nicotinamide levels (≤ 2.1 μM) and elevated nicotinamade (≥ 2.1 μM) at 12 months (mean ± S.E.)

n = 20

n = 13

n = 6

n = 19

Change in total tau (pg/mL)

100 ± 66

1.6 ± 70

−35 ± 84

−8.6 ± 54

Change in pTau₁₈₁ (pg/mL)

10 ± 9.3

0.1 ± 8.5

1.1 ± 14

0.4 ± 7

Change in Aβ40 (pg/mL)

−1961 ± 1002

−2530 ± 754

−1823 ± 1094

−2307 ± 593

Change in Aβ42 (pg/mL)

−103 ± 72

−151 ± 52

−75 ± 44

−127 ± 38

Change in Aβ42/40 (%)

−4.9 ± 1.5

−4.5 ± 1.8

−2.1 ± 4

−3.7 ± 1.7

Change in total tau/ Aβ42(%)

44 ± 7

43 ± 8

35 ± 15

41 ± 7