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Table 2 Comparison of our analyte concentrations to other publications (all µM ± S.D.). N/A is not available

From: Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease

Reference > Analyte

This work Baseline (n = 47)

Chu et al. [12] (n = 659)

Ibrahim et al. [13] (n = 54)

Clement et al. [14] (n = 10)

Seyedsadjadi et al. [15] (n = 100)

Galla et al. [16] (n = 10)

Plasma Nicotinamide

0.5 ± 0.1

0.9 ± 0.02

1.2 ± 0.14

38 ± 11

32 ± 11

N/A

Plasma methyl-nicotinamide

0.14 ± 0.03

0.1 ± 0.002

N/A

0.05 ± 0.01

0.033 ± 0.012

0.185 ± 0.116

Plasma NAD+

 < 1.2

N/A

N/A

0.008 ± 0.02

0.023 ± 0.012

N/A

CSF Nicotinamide

 < 0.4

N/A

N/A

N/A

N/A

N/A

CSF methyl-nicotinamide

 < 0.1

N/A

N/A

N/A

N/A

0.039

 ± 0.025