Fig. 4

The effect of cornuside on NLRP3 inflammasome in Aβ₁₋₄₂ intracerebroventricular injected mice. Data are expressed as the mean ± SEM (n = 4–6). A, B. Representative images of NLRP3 and ASC in the hippocampus and cortex (scale bar: 40 μm). C-F. Fold changes of NLRP3 and ASC are displayed. G, H. Protein levels of NLRP3, GSDMD, ASC, Caspase-1, and IL-1β. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. control group; ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001 vs. model group