Table 1 Clinical characteristics of participants according to the data-driven cluster groups using microbiome data
From: Brain age mediates gut microbiome dysbiosis-related cognition in older adults
Group 1 (N = 191) | Group 2 (N = 97) | |||
|---|---|---|---|---|
N, or mean | %, or SD | N, or mean | %, or SD | |
Age | 71.84 | 7.06 | 73.84 | 6.30 |
Sex (female) | 130 | 68.06 | 70 | 72.16 |
CDR | ||||
0 | 6 | 3.14 | 14 | 1.03 |
0.5 | 158 | 82.72 | 74 | 76.29 |
1 | 23 | 12.04 | 19 | 19.59 |
2 | 4 | 2.09 | 3 | 3.09 |
Dx | ||||
SCD | 11 | 5.70 | 8 | 8.20 |
MCI | 137 | 72.00 | 63 | 65.30 |
Dementia | 43 | 22.30 | 26 | 26.50 |
CDR-SB | 2.61 | 2.00 | 3.02 | 2.16 |
MMSE | 23.40 | 4.93 | 22.86 | 4.82 |
MADRS | 10.06 | 12.39 | 15.70 | 12.44 |
BAI | 8.53 | 10.96 | 9.58 | 10.89 |
Lifetime alcohol consumption | 17896.61 | 36091.06 | 11272.29 | 36583.95 |
MNA | 20.09 | 5.48 | 20.67 | 4.76 |
BMI | 23.82 | 3.32 | 23.94 | 3.60 |
Brain age residual | -0.09 | 0.97 | 0.19 | 1.01 |
Amyloid PET SUVR (N = 185, 96) | 0.67 | 0.16 | 0.67 | 0.16 |
Plasma Aβ42 | 6.44 | 3.74 | 6.40 | 3.72 |
Plasma Aβ40 (N = 103, 47) | 178.43 | 63.90 | 179.19 | 65.24 |
Plasma pTau 217 | 3.00 | 1.69 | 3.03 | 1.70 |
Bacteroidota/Firmicutes ratio | 0.027 | 0.075 | 0.473 | 0.475 |