Brain age mediates gut microbiome dysbiosis-related cognition in older adults

Table 2 Factors associated with cluster groups identified by elastic net regression

	fcoeff average	fcoeff SD	P vales pooled	Compared to cluster 2, cluster 1 has
Chronological age^*	0.001000	0.000018	0.000007	lower age
Brain age_residual^*	0.000900	0.000002	0.000035	lower brain age
Amyloid PET SUVR^*	0.000800	0.000070	0.001000	lower amyloid
CDR-SB^*	0.000600	0.000008	0.019000	better overall cognitive function
BAI^*	-0.001000	0.000002	0.000002	higher anxiety
Lifetime Alcohol consumption^*	-0.000900	0.000002	0.000011	higher lifetime drinking
MMSE	-0.000321	0.000026	0.565343
MADRS	-0.000028	0.000025	0.999968
BMI	0.000136	0.000015	0.980270
Plasma pTau 217	0.000133	0.000013	0.981084
Plasma Aβ42	-0.000241	0.000033	0.812965

Abbreviations: SD, standard deviation; SUVR, standardized uptake value; CDR-SB, clinical dementia rating sum of box; BAI, Beck anxiety inventory; MMSE, mini-mental state examination; MADRS, Montgomery-Asberg depression rating scale; BMI, body mass index. *P < 0.05

ISSN: 1758-9193