Table 3 Mediation analysis among cluster groups, brain age, and MMSE
From: Brain age mediates gut microbiome dysbiosis-related cognition in older adults
Coeff (ß) | SE | T | P value | LLCI | ULCI | |
|---|---|---|---|---|---|---|
Unadjusted analysis | ||||||
Outcome: Brain age residual | ||||||
Cluster group | 0.283 | 0.122 | 2.316 | 0.021* | 0.044 | 0.523 |
Outcome: MMSE | ||||||
Cluster group | -0.195 | 0.595 | -0.328 | 0.743 | -1.361 | 0.971 |
Brain age residual | -1.244 | 0.284 | -4.382 | < 0.001* | -1.800 | -0.687 |
Indirect effect | -0.352 | 0.172 | -2.047 | 0.041* | -0.690 | -0.015 |
Direct effect | -0.195 | 0.595 | -0.328 | 0.743 | -1.361 | 0.971 |
Total effect | -0.547 | 0.609 | -0.899 | 0.368 | -1.740 | 0.646 |
Adjusted analysis | ||||||
Outcome: Brain age residual | ||||||
Cluster group | 0.436 | 0.193 | 2.262 | 0.024* | 0.118 | 0.883 |
Sex | -0.004 | 0.127 | -0.035 | 0.972 | -0.254 | 0.245 |
Age | -0.002 | 0.009 | -0.196 | 0.845 | -0.019 | 0.015 |
Education | 0.005 | 0.013 | 0.360 | 0.719 | -0.020 | 0.029 |
Outcome: MMSE | ||||||
Cluster group | -0.195 | 0.545 | -0.358 | 0.720 | -1.264 | 0.873 |
Brain age residual | -1.288 | 0.258 | -5.000 | < 0.001* | -1.793 | -0.783 |
Sex | -0.035 | 0.557 | -0.063 | 0.950 | -1.126 | 1.056 |
Age | 0.047 | 0.038 | 1.245 | 0.213 | -0.027 | 0.122 |
Education | 0.427 | 0.055 | 7.777 | < 0.001* | 0.319 | 0.534 |
Indirect effect | -0.370 | 0.176 | -2.109 | 0.035* | -0.714 | -0.026 |
Direct effect | -0.195 | 0.545 | -0.358 | 0.720 | -1.264 | 0.873 |
Total effect | -0.565 | 0.563 | -1.004 | 0.315 | -1.669 | 0.538 |