Table 4 Mediation analysis among cluster groups, brain age, and CDR-SB
From: Brain age mediates gut microbiome dysbiosis-related cognition in older adults
Coeff (ß) | SE | T | P value | LLCI | ULCI | |
|---|---|---|---|---|---|---|
Unadjusted analysis | ||||||
Outcome: Brain age residual | ||||||
Cluster group | 0.283 | 0.122 | 2.316 | 0.021* | 0.044 | 0.523 |
Outcome: CDR-SB | ||||||
Cluster group | 0.288 | 0.252 | 1.140 | 0.254 | -0.207 | 0.783 |
Brain age residual | 0.425 | 0.120 | 3.524 | < 0.001* | 0.188 | 0.661 |
Indirect effect | 0.120 | 0.062 | 1.935 | 0.053 | -0.002 | -0.242 |
Direct effect | -0.195 | 0.595 | -0.328 | 0.743 | -1.361 | 0.971 |
Total effect | -0.547 | 0.609 | -0.899 | 0.368 | -1.740 | 0.646 |
Adjusted analysis | ||||||
Outcome: Brain age residual | ||||||
Cluster group | 0.436 | 0.193 | 2.262 | 0.024* | 0.118 | 0.883 |
Sex | -0.004 | 0.127 | -0.035 | 0.972 | -0.254 | 0.245 |
Age | -0.002 | 0.009 | -0.196 | 0.845 | -0.019 | 0.015 |
Education | 0.005 | 0.013 | 0.360 | 0.719 | -0.020 | 0.029 |
Outcome: CDR-SB | ||||||
Cluster group | 0.301 | 0.255 | 1.182 | 0.237 | -0.198 | 0.800 |
Brain age residual | 0.425 | 0.120 | 3.533 | < 0.001* | 0.189 | 0.661 |
Sex | 0.108 | 0.260 | 0.417 | 0.677 | -0.401 | 0.618 |
Age | -0.006 | 0.018 | -0.332 | 0.740 | -0.041 | 0.029 |
Education | -0.014 | 0.026 | -0.550 | 0.583 | -0.064 | 0.036 |
Indirect effect | 0.122 | 0.063 | 1.943 | 0.052 | -0.001 | 0.246 |
Direct effect | 0.301 | 0.255 | 1.181 | 0.238 | -0.198 | 0.801 |
Total effect | 0.423 | 0.258 | 1.641 | 0.101 | -0.082 | 0.929 |