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Table 1 Case-by-case evaluation

From: Long-term surveillance of the anti-amyloid monoclonal antibody lecanemab: rights and duties of pharmacovigilance

Patient

Gender; Age, in years

Reporter country

Co-reported events

Start date

Event date

Time to onset, in days

Co-reported drugs as potential confounders*

Co-reported drugs influencing gene transcription

#1

M; 79

Japan

None

2020-11-06

2023-03-17

862

sitagliptin, ipragliflozin

None

#2

F; 87

USA

jaundice

2019-08-05

2023-02-08

1284

None

raloxifene

#3

F; 74

Japan

femur fracture

2019-02-20

2022-08-11

1269

None

bazedoxifene

  1. * Diabetes can increase the risk of cancer per se (the so-called cofounding by indication); ipragliflozin is a sodium-glucose cotransporter 2 inhibitor used in type 2 diabetes mellitus, whereas sitagliptin is a dipeptidyl peptidase-4 inhibitors, a pharmacological class that has been also potentially associated with pancreatitis and pancreatic carcinoma