Fig. 2
From: TREM2 risk variants and associated endophenotypes in alzheimer’s disease
TREM2 effect on AD clinical measures comparing TREM2 risk variant carriers vs. non-carriers. Shown here are standardized betas of linear regression models adjusted for age and sex; MMSE at baseline and neuropsychological domains are also adjusted for education level and disease stage. Also shown here are betas of logistic regression models for EEG, cox regression models (Cox), and linear mixed models (LMM) adjusted for age, sex, education level, and disease stage; cox regression models are also adjusted for MMSE at baseline. Total n: non-TREM2-carriers=1459; TREM2 risk variant carriers=123; R62H=66, R47H=26; T96K=16; other variants=17. Other TREM2 variants include: D87N, G58A, Q33X, C51Y, R47G, S31F, and A105V. Abbreviations: Aβ42 = Beta-Amyloid 42; AD = Alzheimer’s Disease; CSF = Cerebrospinal Fluid; Cox = Cox regression models; EEG = Electroencephalogram; FDR = False Discovery Rate; LMM = Linear Mixed Models; MMSE = Mini-Mental State Examination; pTau-181 = phosphorylated Tau-181; R47H = p.Arg47His; R62H = p.Arg62His; T96K = p.Thr96Lys; TREM2 = Triggering Receptor Expressed on Myeloid Cells 2