Fig. 4
From: TREM2 risk variants and associated endophenotypes in alzheimer’s disease
Effect of TREM2 variants on cognitive decline in symptomatic AD patients compared to non-carriers. a) b) Shown here are linear mixed models with 95% confidence interval, adjusted for age, sex, education level, disease stage (MCI/dementia). a TREM2 mutation carriers vs. non-carriers. b TREM2 mutation carriers stratified by mutations vs. non-carriers. Total n: non-TREM2-carriers=1444; TREM2 risk variant carriers=120; R62H=66, R47H=24; T96K=15; other variants=17. Other TREM2 variants include: D87N, G58A, Q33X, C51Y, R47G, S31F, and A105V. Abbreviations: MMSE = Mini-Mental State Examination; R47H = p.Arg47His; R62H = p.Arg62His; T96K = p.Thr96Lys; TREM2 = Triggering Receptor Expressed on Myeloid Cells 2.