Fig. 5
From: TREM2 risk variants and associated endophenotypes in alzheimer’s disease
TREM2 effect on cortical thickness and subcortical volumes measured on quantitative imaging analyses using MRI compared to non-carriers. Shown here are standardized betas adjusted for age, sex, and estimated intracranial volume. Total n: non-TREM2-carriers=974; TREM2 risk variant carriers=95; R62H=53, R47H=18; T96K=11; other variants=14. Other TREM2 variants include: D87N, G58A, Q33X, C51Y, R47G, S31F, and A105V. Abbreviations: A = Anterior; R47H = p.Arg47His; R62H = p.Arg62His; p.T96K = Thr96Lys; R = Right; TREM2 = Triggering Receptor Expressed on Myeloid Cells 2.