Table 2 Demographics of cohort at baseline stratified by TREM2 variant carriership
From: TREM2 risk variants and associated endophenotypes in alzheimer’s disease
Main analysis | Exploratory analysis | |||||||
|---|---|---|---|---|---|---|---|---|
TREM2 variant carriers | ||||||||
Total | Non-carriers | All TREM2 carriers | p-value | R62H | R47H | T96K | Otherd | |
Total | 1582 (100) | 1459 (92) | 123 (8) | 66 (4) | 26 (2) | 16 (1) | 17 (1) | |
AD-dementia | 1364 (86) | 1263 (87) | 101 (82) | 0.215 | 53 (80) | 23 (88) | 15 (94) | 12 (71) |
MCI-AD | 218 (14) | 196 (13) | 22 (18) | 13 (20) | 3 (12) | 1 (6) | 5 (29) | |
Female | 824 (52) | 757 (52) | 67 (54) | 0.647 | 36 (55) | 11 (42) | 12 (75) | 9 (53) |
Education, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 0.697 | 1 (0–2) | 1 (0–2) | 1 (0.75–1) | 1 (0–2) |
Positive family historya,e | 691 (46) | 623 (45) | 68 (57) | 0.021* | 35 (53) | 15 (62) | 9 (56) | 11 (69) |
ApoE-ε4 carrierb | 1076 (69) | 990 (69) | 86 (71) | 0.708 | 47 (72) | 16 (62) | 13 (87) | 11 (65) |
Age at diagnosis, mean ± SD | 64.4 ± 7.0 | 64.4 ± 7.0 | 64.4 ± 7.1 | 0.924 | 65.2 ± 6.5 | 64.6 ± 9 | 61.4 ± 6.7 | 64.4 ± 5.8 |
Died | 949 (60) | 878 (60) | 71 (58) | 0.662 | 35 (53) | 22 (85) | 7 (44) | 8 (47) |
Age at deathc, mean ± SD | 71 ± 7.7 | 71.1 ± 7.7 | 70.4 ± 7.9 | 0.496 | 70.4 ± 6.8 | 70.5 ± 9.7 | 69.9 ± 9.7 | 71.7 ± 6.5 |