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Table 3 Effect of TREM2 variants on cognitive decline (in MMSE) stratified by TREM2 mutation carriers compared to non-carriers

From: TREM2 risk variants and associated endophenotypes in alzheimer’s disease

 

Estimate

Standard Error

p-value

p-value FDR-corrected✦

Model 1

    

Time * TREM2 mutation carrier

−0.63

0.25

1.10 × 10–2*

9.37 × 10–2✦

Model 2

    

Time * R62H

0.58

0.62

0.35

NA

Time * R47H

−1.4

0.61

2.07 × 10–2*

NA

Time * T96K

−0.54

0.31

8.52 × 10–2

NA

Time * Other TREM2 variants

−1.75

0.74

1.82 × 10–2*

NA

  1. Shown here are betas derived from linear mixed models with standard error adjusted for age, sex, education level, and disease stage (MCI/dementia), and represent the group * time interaction with non-carriers serving as the reference group. Model 1 is TREM2 mutation carriers versus non-carriers. Model 2 is categories of TREM2 mutation carriers versus non-carriers
  2. ✦ FDR-corrected p < 0.10, *p < 0.05
  3. Other TREM2 variants include: D87N, G58A, Q33X, C51Y, R47G, S31F, and A105V
  4. Abbreviations: FDR False Discovery Rate, MMSE Mini-Mental State Examination, NA Not Available, R47H p.Arg47His, R62H p.Arg62His, T96K p.Thr96Lys, TREM2 Triggering Receptor Expressed on Myeloid Cells 2
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Alzheimer's Research & Therapy

ISSN: 1758-9193