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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Probing locus coeruleus functional network in healthy aging and its association with Alzheimer’s disease biomarkers using pupillometry

Fig. 1

Schematic illustration of pupil diameter estimation and MRI data acquisition. (A) For HIPPA consideration, a synthetic eye-tracking photo was shown for illustration purposes with the pupil contour line (yellow) superimposed. The time course of the pupil diameter during resting-state functional MRI was obtained from the eye-tracking video. (B) After data acquisition, the functional MRI blood-oxygen level dependent (BOLD) time series was extracted from each voxel in the brain

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