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Table 2 Correlations of functional networks with neuropsychological performance

From: Probing locus coeruleus functional network in healthy aging and its association with Alzheimer’s disease biomarkers using pupillometry

Cluster name

Peak coordinates in MNI space

Neuropsychological assessment

Test domain

r-statistic

P-value

Pupil diameter time series as a seed signal

 

 Anterior supramarginal gyrus left

-58 -38 + 32

FCSRT free recall

Memory

0.580

< 0.001

 Anterior supramarginal gyrus right

+ 68 − 30 + 30

FCSRT free recall

Memory

0.448

0.022

 Superior frontal gyrus left

-16 + 4 + 70

FCSRT free recall

Memory

0.467

0.022

 unlabeled*

+ 20 + 32 − 30

FCSRT free recall

Memory

-0.488

0.016

 Frontal pole right

+ 46 + 48 − 16

Letter Fluency (FAS)

Language and executive

0.456

0.022

 Middle frontal gyrus left

-30 + 36 + 38

TMTA

Executive

0.419

0.044

 Hippocampus left

-22 -10 -18

TMTB– TMTA

Executive

0.451

0.022

First derivative time series as a seed signal

 

 Posterior middle temporal gyrus right

+ 60 − 26 -12

RCFT immediate free recall

Memory

-0.513

0.006

 Vermis 9

+ 0–50 -36

RCFT delayed free recall

Memory

-0.459

0.022

 Hippocampus right

+ 32 − 8 -22

RCFT copy accuracy score

Visuospatial

0.574

< 0.001

 Precuneus*

+ 0–62 + 64

JoLO

Visuospatial

0.497

0.008

  1. MNI, Montreal Neurological Institute; FCSRT, Free and Cued Selective Reminding Test; TMTA, Trail Making Test Part A; TMTB, Trail Making Test Part B; RCFT, Rey Complex Figure Test; JoLO, Judgment of Line Orientation
  2. The associations were evaluated using multiple regression with age and sex as covariates. P-values were adjusted for multiple comparisons using false discovery rate correction
  3. Clusters were named based on the CONN atlas regions of the peak voxels. If the peak voxel was not labeled, the immediately adjacent 26 voxels were scanned, and the cluster was named based on the adjacent voxels’ labels, with an asterisk (*) appended to the end of the cluster name. If neither the peak voxel nor the immediately adjacent voxels were labeled in the CONN atlas, the cluster was named as “unlabeled*”
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Alzheimer's Research & Therapy

ISSN: 1758-9193