Fig. 2
From: Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease
Characterization of integrated protein network modules. a Schematic representation of the workflow for integrating proteomics and protein–protein interaction (PPI) data and evaluation of integrated features. b Stochastic neighbor embedding (tSNE) plot displaying protein modules. c Upper panels: Uniform Manifold Approximation and Projection (UMAP) visualizations of single-nucleus RNA sequencing (snRNA-seq) data for patients with Alzheimer's disease (AD) (GSE174367) [40] clustered according to cell types (left) and conditions (right) Lower panels: expression levels of proteins within the identified modules. d Representative Gene Ontology (GO) terms enriched in each protein module. e Network depicting the closeness among modules. Closeness was defined by averaging BIONIC-derived features within modules, calculating the Euclidean distances among modules, and taking reciprocals