Fig. 5
From: Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease
Histopathological analysis validated the roles of microglia/astrocytes as Aβ-tau moderators in early Alzheimer’s disease. a Schematic of the analytical workflow for linear regression analyses. Samples were sourced from four brain regions: frontal white matter (FWM), hippocampus (HIP), parietal neocortex (PCx), and temporal neocortex (TCx). RNA sequencing and immunohistochemistry data were used [21, 22]. A linear regression was performed, repeated for GFAP and IBA1, and Aβ as predictors of tau interactions. b Significant results of linear regression analyses for each of the four distinct brain regions, with subjects categorized into no-dementia and dementia groups