Fig. 4

Schematic illustration of the analysis process and data from representative participants. (A) Analysis process from initial diffusion weighted imaging (DWI) images to calculate ALPS indices. (B) Analysis process to calculate volume of white-matter hyperintensities (WMH) in regions of interest (ROI) and data from 2 representative subjects from ADNI cohort, which illustrates how higher WMH-Volume in ROI might interfere with ALPS-Index in healthy controls. ALPS: diffusion tensor image analysis along the perivascular space