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Table 3 Group differences between AD (Alzheimers diesease dementia patients) and HC (healthy controls) in the DTI_ALPS-Index

From: Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Cohort

Location

AD (mean ± SD)

HC (mean ± SD)

P-Value

Cohens d

ADNI

ALPS_comb

1.080 ± 0.236

1.190 ± 0.132

0.008*

-0.575

ADNI

ALPS_R

1.088 ± 0.173

1.207 ± 0.154

0.001*

-0.727

ADNI

ALPS_L

1.123 ± 0.186

1.174 ± 0.147

0.149

-0.304

DELCODE

ALPS_comb

1.262 ± 0.180

1.336 ± 0.197

0.035*

-0.392

DELCODE

ALPS_R

1.245 ± 0.208

1.332 ± 0.254

0.048*

-0.375

DELCODE

ALPS_L

1.278 ± 0.185

1.341 ± 0.199

0.081

-0.328

ActiGliA

ALPS_comb

1.217 ± 0.122

1.356 ± 0.139

0.004*

-1.063

ActiGliA

ALPS_R

1.217 ± 0.183

1.336 ± 0.165

0.055

-0.683

ActiGliA

ALPS_L

1.217 ± 0.104

1.377 ± 0.152

0.001*

-1.229

  1. Abbreviation: ALPS_R, ALPS_L: calculated ALPS-Index on right R and left L hemisphere of the brain. ALPS_comb: combined ALPS-Index, by calculating the mean of Index for right and left hemisphere. SD: Standard deviation.* significant difference with P < 0.05. Participants with WMH contamination of the ALPS calculation were omitted from the analysis. Calculated using an ANOVA adjusted for age and sex