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Table 5 Correlation between ALPS indices and Amyloid-beta 42 in AD

From: Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

 

ActiGlia

ADNI

DELCODE

Aβ42

Aβ42

Aβ42

β

SE

Adj-R²

p-value

β

SE

Adj-R²

p-value

β

SE

Adj-R²

p-value

ALPS_comb

0.18

0.00

0.39

0.471

0.09

0.00

-0.14

0.707

-0.12

0.00

0.09

0.437

ALPS_R

0.24

0.00

0.60

0.249

-0.08

0.00

-0.01

0.705

-0.06

0.00

0.13

0.679

ALPS_L

0.00

0.00

-0.12

0.997

0.43

0.00

0.24

0.042*

-0.16

0.00

0.03

0.306

  1. Abbreviations: ALPS_R, ALPS_L: calculated ALPS index on right R and left L hemisphere of the brain. ALPS_comb: combined ALPS index, by calculating the mean of Index for right and left hemishphere; adj-R2: adjusted R2; SE: Standard error; * significant difference with P < 0.05. Calculated with multivariate linear regression analyses, using age, sex, and years of education as confounding variables