Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Table 6 Correlation between ALPS indices and WMH found in the 5 mm-sphere- ROI in the 3 cohorts

	WMH Volume detected in ROI (left and right side combined)
	ActiGlia (n = 2)		ADNI (n = 36)		DELCODE (n = 10)
	β	p-value	β	p-value	β	p-value
ALPS_comb	0.067	0.675	-0.103	0.373	-0.215	0.014*
ALPS_R	0.072	0.625	-0.217	0.040*	-0.208	0.022*
ALPS_L	0.047	0.784	-0.068	0.562	-0.171	0.049*

Abbreviations: ALPS_R, ALPS_L: calculated ALPS-Index on right R and left L hemisphere of the brain. ALPS_comb: combined ALPS-Index, by calculating the mean of Index for right and left hemishphere. * significant difference with P < 0.05. Calculated with multivariate linear regression analyses, using age, sex, diagnose and years of education as confounding variable

ISSN: 1758-9193