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Table 7 Correlation between ALPS indices and WMH found in the 5 mm-sphere- ROI with the 3 cohorts combined (n = 48)

From: Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

WMH Volume detected in ROI

 

WMH_comb

WMH_R

WMH_L

β

SE

Adj-R ²

p-value

β

SE

Adj-R ²

p-value

β

SE

Adj-R ²

p-value

ALPS_comb

0.154

0.053

0.18

0.010*

-0.142

0.084

0.18

0.018*

-0.133

0.109

0.18

0.027*

ALPS_R

-0.202

0.058

0.16

0.001*

-0.202

0.093

0.16

0.001*

-0.154

0.120

0.14

0.013*

ALPS_L

-0.117

0.051

0.17

0.055*

-0.095

0.081

0.16

0.120

-0.118

0.104

0.17

0.052

  1. Abbreviations: aR ²= adjusted R squared; SE: Standard Error; ALPS_R, ALPS_L: calculated ALPS-Index on right R and left L hemisphere of the brain. ALPS_comb: combined ALPS-Index, WMH_R, WMH_L: volume of WMH in 5 mm sphere ROI on right and left hemisphere, WMH_comb: left and right side combined. * significant difference with P < 0.05. Calculated with multivariate linear regression analyses, using age, sex, diagnose and cohort as confounding variable
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Alzheimer's Research & Therapy

ISSN: 1758-9193