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Table 3 Hazard ratios and 95% confidence intervals of all-cause dementia by diabetes status in stroke patient according to the prespecified subgroup

From: Diabetes status, duration, and risk of dementia among ischemic stroke patients

Subgroup

Glycemic Status

N

All-cause Dementia

IR, per 1000 PY

HR (95% CI)

Model1

Model2

Model3

Age

40–64

Normal

30,592

1,365

5.51

1 (Ref.)

1 (Ref.)

1 (Ref.)

IFG

14,434

624

5.36

0.974 (0.886,1.071)

0.962 (0.875,1.058)

0.960 (0.873,1.056)

NODM

633

31

6.23

1.135 (0.795,1.621)

1.172 (0.821,1.673)

1.148 (0.804,1.639)

 < 5 years

5,826

366

7.96

1.452 (1.294,1.630)

1.375 (1.225,1.544)

1.345 (1.197,1.511)

 ≥ 5 years

5,595

523

12.21

2.238 (2.024,2.476)

1.893 (1.710,2.095)

1.836 (1.658,2.033)

 ≥ 65

Normal

29,773

7,885

39.25

1 (Ref.)

1 (Ref.)

1 (Ref.)

IFG

15,439

3,992

38.34

0.977 (0.940,1.015)

0.988 (0.951,1.026)

0.983 (0.946,1.021)

NODM

870

235

45.58

1.182 (1.038,1.346)

1.006 (0.884,1.146)

0.992 (0.871,1.130)

 < 5 years

6,797

2,021

45.92

1.178 (1.122,1.237)

1.267 (1.206,1.332)

1.248 (1.188,1.312)

 ≥ 5 years

8,831

2,802

51.23

1.326 (1.270,1.385)

1.430 (1.369,1.494)

1.399 (1.338,1.462)

p for interaction

   

 < 0.0001

 < 0.0001

 < 0.0001

Sex

Male

Normal

26,680

3,588

18.43

1 (Ref.)

1 (Ref.)

1 (Ref.)

IFG

15,239

1,927

17.23

0.934 (0.884,0.988)

0.968 (0.915,1.023)

0.973 (0.921,1.029)

NODM

865

112

19.02

1.039 (0.861,1.254)

0.980 (0.812,1.183)

0.967 (0.801,1.168)

 < 5 years

6,793

1,029

21.34

1.162 (1.084,1.245)

1.295 (1.207,1.388)

1.276 (1.190,1.369)

 ≥ 5 years

7,441

1,363

27.16

1.490 (1.400,1.586)

1.438 (1.351,1.532)

1.410 (1.323,1.502)

Female

Normal

33,685

5,662

22.29

1 (Ref.)

1 (Ref.)

1 (Ref.)

IFG

14,634

2,689

24.74

1.112 (1.062,1.164)

0.994 (0.949,1.041)

0.982 (0.938,1.029)

NODM

638

154

36.26

1.648 (1.404,1.934)

1.026 (0.874,1.204)

1.011 (0.861,1.187)

 < 5 years

5,830

1,358

32.52

1.468 (1.384,1.558)

1.281 (1.207,1.360)

1.260 (1.186,1.338)

 ≥ 5 years

6,985

1,962

41.45

1.887 (1.793,1.987)

1.547 (1.469,1.630)

1.507 (1.430,1.588)

p for interaction

   

 < 0.0001

0.4422

0.5317

  1. Model1: crude analysis; Model2: adjustment with age, sex, income, BMI, hypertension, dyslipidemia, and atrial fibrillation; Model3: additional adjustment with smoking, drinking, exercise, HDL, rGTP, proteinuria, chronic kidney disease and depression
  2. Abbreviation: HR hazard ratio, IFG impaired fasting glucose, NODM new-onset diabetes mellitus, IR incidence rate