Fig. 5

Prediction of preclinical PSEN1 mutation carriers using amygdala tau and cognitive-behavioral measures. Receiver operating characteristic analysis output of 6 models comparing the predictive performance of PSEN1 carriership using tau pathology in the basal, lateral and whole amygdala with and without cognitive (CERAD Word List Learning and TMT-B time) and neuropsychiatric (GDS and GAI) measures as additional predictors. AUC = Area under the curve, CERAD = Consortium to Establish a Registry for Alzheimer’s disease, GAI = Geriatric Anxiety Inventory, GDS = Geriatric Depression Scale, TMT-B = Trail Making Test Part B