Table 1 Demographic and clinical characteristics of the participants in the cross-section cohort
Characteristic | AD + aMCI (n = 245) | PSP (n = 100) | FTD (n = 67) | DLB (n = 72) | HC (n = 184) | p-value1 |
|---|---|---|---|---|---|---|
Sex (Male, %) | 40% | 61% | 60% | 60% | 46% | 0.17 |
Age of onset (Years) | 63.1 ± 9.8 | 65.2 ± 6.9 | 61.9 ± 9.5 | 71.4 ± 9.1 | 67.6 ± 6.5 | < 0.001 |
APOE E42 | 43% | 15% | 31% | 36% | 17% | < 0.001 |
Education (Years) | 9.2 ± 3.6 | 8.7 ± 3.3 | 9.2 ± 3.4 | 8.3 ± 3.7 | 8.1 ± 2.0 | < 0.001 |
MMSE | 16.4 ± 8.4 | 22.0 ± 6.4 | 15.9 ± 9.2 | 14.2 ± 7.4 | 28.9 ± 0.9 | < 0.001 |
MoCA | 11.3 ± 6.8 | 14.0 ± 6.4 | 11.0 ± 7.2 | 7.9 ± 6.0 | ||
CDR | 1.1 ± 0.1 | / | 1.3 ± 0.1 | 1.4 ± 0.1 | ||
CSF Aβ42 (pg/ml) | 392.3 ± 230.0 | 1,292.2 ± 772.1 | 757.4 ± 389.6 | 506.5 ± 536.2 | ||
CSF Aβ40 (pg/ml) | 6,566.6 ± 4,219.4 | 10,982.8 ± 7,062.0 | 7,618.5 ± 6,280.7 | 7,604.6 ± 6,423.5 | ||
CSF Aβ42/40 | 0.07 ± 0.04 | 0.1 ± 0.04 | 0.1 ± 0.1 | 0.09 ± 0.07 | ||
CSF t-tau (pg/ml) | 397.6 ± 268.5 | 225.4 ± 81.5 | 225.0 ± 162.0 | 282.3 ± 161.6 | ||
CSF p-tau (pg/ml) | 94.0 ± 53.2 | 27.0 ± 13.6 | 25.6 ± 12.6 | 55.2 ± 33.8 |