Table 1 Demographic, clinical, and biomarker characteristics of the whole AD sample stratified by sex

Age at baseline visit

74.1 (10)

76.25 (11)

U= 14623; P=0.027

Age at AD onset

72 (10)

73.5 (11)

U=14523.5; P=0.036

Level of education

(high/low, %high)

46/110

29%

100/64

61%

X²=31.95; P<0.001

MMSE at baseline visit

23 (4)

23 (4)

U=13427.5; P=0.438

APOE e4 carriers

(yes/no, % carriers)

102/54

(65%)

125/39

(76%)

X² =4.553; P=0.033

CSF t-Tau

(>254/<254, %>254)

74/8

(90%)

77/23

(77%)

X²= 5.592; P=0.018

CSF pTau

(>24.3/<24.3, %>24.3)

71/11

(87%)

82/18

(82%)

X²= 0.707; P=0.400

CSF Amyloid-β

(<981/ >981, %<981)

80/2

(98%)

97/3

(97%)

X²= 0.053; P=0.818

Anart total

15 (15)

16 (12)

U= 5363; P=0.557

GDS

1 (2)

2 (2)

U= 9575.5; P=0.312

CDR

0.5 (1)

0.5 (1)

U = 7362; P=0.506

WM-hypo/eTIV

at baseline visit

5.13·10^-5

(6.86·10^-6)

4.46·10^-5

(6.42·10^-6)

U= 4504; P<0.001

Cohort

(ADNI, J-ADNI, AIBL)

91/52/13

116/38/10

X²= 5.4; P=0.067