Table 2 Demographic, clinical, and biomarker characteristics of the AD trajectories stratified by sex
From: Atrophy trajectories in Alzheimer’s disease: how sex matters
Minimal atrophy (MA, N=189) | Limbic predominant (LPA, N=93) | Limbic predominant plus (LPA +, N=23) | Diffuse atrophy (DA, N=5) | Hippocampal sparing (HS, N=10) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Sex | W (N=90) | M (N=99) | W (N=45) | M (N=48) | W (N=14) | M (N=9) | W (N=3) | M (N=2) | W (N=4) | M (N=6) |
Age at baseline visit | 74.85 (9)b | 76.6 (10)b | 74.1 (11) | 76.3 (12) | 71.8 (8)a | 79.4 (9)a | 63.3 | 75.65 | 65.9 (12) | 61.8 (9) |
Age at AD onset | 71.5 (9.3) | 73 (10) | 72.5 (11.5) | 74 (11) | 70 (9.5)a | 78 (8)a | 62 | 75 | 65.5 (12.5) | 60.7 (7.4) |
Level of education (high/low, % high) | 24/66 (27%)a | 61/38 (62%)a | 13/32 (29%)a | 29/19 (60%)a | 5/9 (36%) | 4/5 (44%) | 1/2 (33%) | 2/0 (100%) | 3/1 (75%) | 4/2 (67%) |
MMSE at baseline visit | 23 (4) | 23 (4) | 23(4) | 23(3) | 23 (3) | 23 (5) | 25 | 24.5 | 23 (2) | 22 (7) |
APOE e4 carriers (yes/no, % carriers) | 62/28 (69%)b | 80/19 (81%)b | 29/16 (64%) | 33/14 (70%) | 8/6 (57%) | 8/1 (89%) | 1/2 (33%) | 2/0 (100%) | 2/2 (50%) | 2/4 (33%) |
CSF t-Tau (>254/<254, %>254) | 42/5 (89%) | 48/13 (79%) | 23/2 (92%)b | 20/8 (71%)b | 7/1 (88%) | 4/1 (80%) | 1/0 (100%) | 2/0 (100%) | 1/0 (100%) | 3/1 (75%) |
CSF pTau (>24.3/<24.3, %>24.3) | 41/6 (87%) | 51/10 (84%) | 22/3 (88%) | 22/6 (79%) | 6/2 (75%) | 4/1 (80%) | 1/0 (100%) | 2/0 (100%) | 1/0 (100%) | 3/1 (75%) |
CSF Amyloid-β (<981/ >981, %<981) | 46/1 (98%) | 61/0 (100%) | 24/1 (96%) | 26/2 (93%) | 8/0 (100%) | 5/0 (100%) | 1/0 (100%) | 2/0 (100%) | 1/0 (100%) | 3/1 (75%) |
Anart total | 16 (16) | 16.5 (14) | 12 (17) | 17 (12) | 15 (16) | 12.5 (11) | 26.5 | 10.5 | 19 | 10 (11) |
GDS | 1 (2) | 2 (1) | 1 (1) | 2 (2) | 0 (3) | 2 (3) | 2 | 1 | 2.5 | 1.5 (2) |
CDR | 0.5 (1) | 0.5 (1) | 0.5 (1) | 1 (1) | 1 (1) | 0.5 (1) | 0.5 | Missing data | 0.5 | 0.75 (1) |
WM-hypo /eTIV | 5.13·10-5 (6.31·10-6)a | 4.49·10-5 (6.14·10-6)a | 5.08·10-5 (8.50·10-6)a | 4.45·10-5 (6.50·10-6)a | 5.17·10-5 (6.38·10-6)a | 4.48·10-5 (1.07·10-6)a | 5.43·10-5 | 4.30·10-5 | 5.23·10-5 (1.26·10-5) | 4.38·10-5 (6.99·10-6) |