Fig. 3
From: Novel CSF β-synuclein-specific assays signal early synaptic degeneration in Alzheimer’s disease
Comparative analysis of CSF β-syn measurements using N-terminus, mid-region, and C-terminus ELISAs in the proof-of-concept cohort. (A-C) Box plots illustrating the β-syn levels measured at different epitopes (N-terminus, mid-region, and C-terminus) in the control and AD dementia groups. (D) ROC curves for β-syn measured at different epitopes: N-terminus β-syn: AUC = 0.91 (95% CI: 0.82–0.99), Mid-region β-syn: AUC = 0.92 (95% CI: 0.85–0.99), and C-terminus β-syn: AUC = 0.96 (95% CI: 0.91–1.00). The p values represent the results of the Wilcoxon test for comparisons of group levels. β-syn: beta-synuclein, ROC: receiver operating characteristic, AUC: area under the curve, AD: Alzheimer’s disease