Fig. 6
From: Novel CSF β-synuclein-specific assays signal early synaptic degeneration in Alzheimer’s disease
Correlation plots between CSF β-syn levels measured with the N-terminus, mid-region, and C-terminus ELISAs and between CSF β-syn levels and the core AD biomarkers, Mini-Mental State Examination (MMSE) scores, and trail making test B/A ratio scores in the clinical cohort. A-C Scatter plots illustrating the correlations between the N-terminus, mid-region, and C-terminus β-syn levels in CSF. D-F Correlations between CSF Aβ42 and β-syn levels. G-I Correlations between pTau181 and β-syn levels. J-L Correlations between CSF Tau and β-syn levels. M–O Correlations between MMSE scores and β-syn levels. P-R Correlations between the TMT B/A ratio and β-syn levels. The colors represent different clinical groups: control (dark green), SCD-AD (yellow), MCI-AD (light blue), and AD-dem (magenta). Each plot includes a Spearman correlation coefficient in R-squared for each of the clinical groups and in (overall rho) for the overall correlation of all clinical groups along with the associated p value. The shaded gray areas represent the 95% confidence intervals for the linear regression lines. CSF: cerebrospinal fluid, β-syn: beta-synuclein, Aβ42: amyloid beta1–42; pTau181: phosphorylated tau at threonine 181, TMT B/A: trail-making test B score divided by the A test score