Fig. 5

Personalized Brain Network Models present configurations with levels of synaptic degeneration proportional to cognitive decline severity. A Distribution of \(cp\) parameters for BNMs constructed from CTR subjects. B Distribution of \(cp\) parameters for SCD BNMs. This is the only bimodal distribution among all groups, consistently with experimental FC results. C Distribution of \(cp\) parameters for MCI BNMs. D Assortativity of CTR BNMs. Blue dots represent Assortativity values of CTR BNMs, with dot width representing numerosity. Red dots are Assortativity values of the network at different \(cp\) values. E Assortativity of SCD and MCI patients. Brown dots represent Assortativity values of SCD and MCI BNMs combined, notation is the same as in (D). F Distribution of Assortativity values for CTR BNMs, the distribution is extremely narrow. G Distribution of Assortativity values for SCD BNMs, displaying high dispersion. H Distribution of Assortativity values for MCI BNMs. I Distribution of personalized BNM parameters for CTR subjects. The distribution is unimodal, centred at low values of network degeneration. J Distribution of personalized BNM parameters for SCD patients. The distribution is bimodal, with a peak at low values and a peak at intermediate values of network degeneration. K Distribution of personalized BNM parameters for MCI patients. The distribution is unimodal, centred at intermediate values of network degeneration. L Population histogram of BNMs near the peak at low \(lp\) levels (\(lp\)=0.12) divided per group. Histogram was computed from the personalized values of \(cp\) and \(lp\) parameters (see Methods, “Personalized Brain Network Models and parameter estimation” paragraph). Peak central \(cp\) and \(lp\) values are reported. M Population histogram of BNMs near the peak at intermediate \(lp\) levels (\(lp\)=0.56) divided per group, same notation as in (L). N Population histogram of BNMs near the peak at high \(lp\) levels (\(lp\)=0.96) divided per group, same notation as in (L). The peak analysis showed how participants from different groups clustered at levels of synaptic degeneration proportional to cognitive decline severity. Significance was computed by bootstrapping original values (see Methods, “Statistical tests” paragraph). Significance notation: * stands for p < 0.05, ** stands for p < 0.0025. Abbreviations: \(cp\): connectivity parameter; CTR: Control; cv: coefficient of variation; \(lp\): local parameter; MCI: Mild Cognitive Impairment; SCD: Subjective Cognitive Decline