Table 2 Associations between each SCC metric and biomarker on the entire sample (N = 254), adjusted for the following covariates: age, gender, race/ethnicity, cognitive status (MCI/CU), years of education, and depression (as measured by the geriatric depression Scale). Bold indicates significant association at \(\:\alpha\:=0.05\)
SCC Metric | Aβ40 | Aβ42 | GFAP | NfL | p-tau181 | Aβ42 / Aβ40 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | |
DMLC Total | 0.07 (-0.04 to 0.17) | 0.226 | 0.00 (-0.12 to 0.11) | 0.946 | -0.01 (-0.14 to 0.11) | 0.823 | 0.03 (-0.07 to 0.12) | 0.569 | 0.21 (0.08 to 0.33) | 0.001 | -0.11 (-0.23 to 0.00) | 0.056 |
DMLC Memory | 0.08 (-0.02 to 0.19) | 0.125 | 0.02 (-0.10 to 0.14) | 0.738 | 0.00 (-0.13 to 0.12) | 0.939 | 0.06 (-0.04 to 0.16) | 0.216 | 0.23 (0.10 to 0.35) | < 0.001 | -0.10 (-0.22 to 0.02) | 0.092 |
DMLC Not-Memory | 0.03 (-0.08 to 0.14) | 0.58 | -0.04 (-0.15 to 0.08) | 0.544 | -0.03 (-0.15 to 0.10) | 0.695 | -0.02 (-0.12 to 0.07) | 0.656 | 0.14 (0.02 to 0.27) | 0.026 | -0.11 (-0.23 to 0.00) | 0.059 |
CCI-20 Total | 0.00 (-0.11 to 0.12) | 0.964 | -0.08 (-0.20 to 0.04) | 0.186 | -0.02 (-0.16 to 0.12) | 0.764 | 0.03 (-0.07 to 0.13) | 0.556 | 0.13 (-0.01 to 0.26) | 0.061 | -0.12 (-0.25 to 0.00) | 0.052 |
CCI-20 Memory | -0.02 (-0.13 to 0.09) | 0.73 | -0.10 (-0.22 to 0.02) | 0.119 | -0.03 (-0.17 to 0.10) | 0.629 | 0.02 (-0.08 to 0.12) | 0.706 | 0.12 (-0.01 to 0.26) | 0.07 | -0.09 (-0.22 to 0.03) | 0.127 |
CCI-20 Not Memory | 0.04 (-0.07 to 0.16) | 0.438 | -0.03 (-0.16 to 0.09) | 0.585 | 0.01 (-0.13 to 0.14) | 0.903 | 0.04 (-0.06 to 0.15) | 0.397 | 0.11 (-0.03 to 0.24) | 0.128 | -0.14 (-0.27 to -0.02) | 0.024 |