Table 3 Associations between each SCC metric and biomarker stratified by cognitive status (MCI / CU), adjusted for the following covariates: age, gender, race/ethnicity, years of education, and depression (as measured by the geriatric depression Scale). Bold indicates significant association at \(\:\alpha\:=0.05\)
Mild Cognitive Impairment (N = 75) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCC Metric | Aβ40 | Aβ42 | GFAP | NfL | p-tau181 | Aβ42 / Aβ40 | ||||||
Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | |
DMLC Total | 0.30 (0.12 to 0.48) | 0.001 | 0.09 (-0.13 to 0.31) | 0.426 | 0.13 (-0.11 to 0.37) | 0.275 | 0.10 (-0.03 to 0.22) | 0.141 | 0.22 (-0.01 to 0.46) | 0.065 | -0.33 (-0.56 to -0.10) | 0.006 |
DMLC Memory | 0.30 (0.12 to 0.48) | 0.001 | 0.11 (-0.11 to 0.33) | 0.329 | 0.07 (-0.17 to 0.31) | 0.542 | 0.08 (-0.04 to 0.21) | 0.195 | 0.18 (-0.06 to 0.42) | 0.144 | -0.30 (-0.53 to -0.06) | 0.014 |
DMLC Not-Memory | 0.25 (0.07 to 0.44) | 0.007 | 0.05 (-0.17 to 0.26) | 0.677 | 0.21 (-0.02 to 0.44) | 0.079 | 0.10 (-0.02 to 0.23) | 0.111 | 0.27 (0.04 to 0.50) | 0.024 | -0.34 (-0.57 to -0.11) | 0.004 |
CCI-20 Total | 0.19 (0.00 to 0.39) | 0.052 | -0.08 (-0.30 to 0.15) | 0.511 | -0.09 (-0.33 to 0.16) | 0.494 | 0.05 (-0.09 to 0.18) | 0.466 | 0.23 (-0.01 to 0.48) | 0.061 | -0.40 (-0.64 to -0.17) | 0.001 |
CCI-20 Memory | 0.16 (-0.03 to 0.36) | 0.099 | -0.10 (-0.33 to 0.12) | 0.362 | -0.10 (-0.34 to 0.15) | 0.44 | 0.02 (-0.11 to 0.16) | 0.732 | 0.21 (-0.03 to 0.46) | 0.087 | -0.38 (-0.62 to -0.14) | 0.002 |
CCI-20 Not Memory | 0.21 (0.01 to 0.40) | 0.036 | -0.01 (-0.24 to 0.22) | 0.945 | -0.05 (-0.30 to 0.20) | 0.694 | 0.09 (-0.05 to 0.22) | 0.192 | 0.23 (-0.02 to 0.47) | 0.072 | -0.37 (-0.61 to -0.13) | 0.003 |
Cognitively Unimpaired (N = 179) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCC Metric | Aβ40 | Aβ42 | GFAP | NfL | p-tau181 | Aβ42 / Aβ40 | ||||||
Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | |
DMLC Total | -0.05 (-0.18 to 0.08) | 0.468 | -0.04 (-0.18 to 0.09) | 0.545 | -0.09 (-0.24 to 0.06) | 0.234 | -0.01 (-0.13 to 0.12) | 0.895 | 0.20 (0.05 to 0.34) | 0.01 | 0.01 (-0.12 to 0.14) | 0.901 |
DMLC Memory | -0.03 (-0.16 to 0.10) | 0.623 | -0.02 (-0.16 to 0.12) | 0.773 | -0.06 (-0.21 to 0.10) | 0.477 | 0.05 (-0.08 to 0.17) | 0.468 | 0.25 (0.10 to 0.40) | < 0.001 | 0.02 (-0.11 to 0.15) | 0.762 |
DMLC Not-Memory | -0.06 (-0.19 to 0.07) | 0.389 | -0.06 (-0.20 to 0.08) | 0.383 | -0.12 (-0.27 to 0.03) | 0.126 | -0.07 (-0.20 to 0.05) | 0.245 | 0.09 (-0.06 to 0.24) | 0.25 | -0.01 (-0.14 to 0.12) | 0.895 |
CCI-20 Total | -0.10 (-0.24 to 0.04) | 0.145 | -0.09 (-0.23 to 0.06) | 0.249 | 0.01 (-0.15 to 0.18) | 0.862 | 0.02 (-0.12 to 0.16) | 0.773 | 0.05 (-0.11 to 0.21) | 0.551 | 0.04 (-0.10 to 0.18) | 0.592 |
CCI-20 Memory | -0.11 (-0.24 to 0.03) | 0.132 | -0.08 (-0.22 to 0.07) | 0.288 | 0.00 (-0.16 to 0.16) | 0.995 | 0.02 (-0.12 to 0.15) | 0.791 | 0.06 (-0.10 to 0.22) | 0.434 | 0.06 (-0.08 to 0.20) | 0.403 |
CCI-20 Not Memory | -0.07 (-0.21 to 0.07) | 0.334 | -0.08 (-0.23 to 0.07) | 0.31 | 0.04 (-0.13 to 0.21) | 0.647 | 0.02 (-0.12 to 0.16) | 0.8 | 0.01 (-0.16 to 0.17) | 0.944 | -0.01 (-0.16 to 0.13) | 0.842 |