Table 4 Associations between each SCC metric and biomarker stratified by Race / Ethnicity (NH-White & NH-Black) adjusted for the following covariates: age, gender, cognitive status (MCI / CU), years of education, and depression (as measured by the geriatric depression Scale). Bold indicates significant association at \(\:\alpha\:=0.05\)
Non-Hispanic Black (N = 103) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCC Metric | Aβ40 | Aβ42 | GFAP | NfL | p-tau181 | Aβ42 / Aβ40 | ||||||
Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | |
DMLC Total | 0.06 (-0.09 to 0.22) | 0.414 | -0.03 (-0.20 to 0.14) | 0.76 | 0.11 (-0.09 to 0.31) | 0.284 | 0.02 (-0.12 to 0.16) | 0.788 | 0.16 (-0.02 to 0.34) | 0.084 | -0.16 (-0.34 to 0.02) | 0.074 |
DMLC Memory | 0.07 (-0.09 to 0.23) | 0.369 | -0.01 (-0.18 to 0.17) | 0.95 | 0.11 (-0.09 to 0.30) | 0.295 | 0.00 (-0.14 to 0.14) | 0.977 | 0.18 (-0.01 to 0.36) | 0.057 | -0.14 (-0.31 to 0.04) | 0.131 |
DMLC Not-Memory | 0.05 (-0.11 to 0.20) | 0.559 | -0.05 (-0.22 to 0.12) | 0.544 | 0.09 (-0.10 to 0.29) | 0.349 | 0.04 (-0.10 to 0.18) | 0.558 | 0.11 (-0.07 to 0.29) | 0.232 | -0.17 (-0.34 to 0.00) | 0.054 |
CCI-20 Total | 0.03 (-0.13 to 0.19) | 0.748 | -0.11 (-0.28 to 0.07) | 0.228 | 0.03 (-0.17 to 0.24) | 0.746 | -0.01 (-0.15 to 0.14) | 0.938 | 0.19 (0.01 to 0.38) | 0.04 | -0.18 (-0.36 to 0.00) | 0.052 |
CCI-20 Memory | -0.02 (-0.18 to 0.14) | 0.81 | -0.14 (-0.31 to 0.03) | 0.101 | 0.02 (-0.18 to 0.23) | 0.812 | -0.04 (-0.18 to 0.11) | 0.605 | 0.20 (0.02 to 0.38) | 0.032 | -0.15 (-0.33 to 0.03) | 0.105 |
CCI-20 Not Memory | 0.11 (-0.05 to 0.27) | 0.188 | -0.01 (-0.19 to 0.17) | 0.9 | 0.04 (-0.16 to 0.25) | 0.678 | 0.06 (-0.09 to 0.21) | 0.442 | 0.14 (-0.05 to 0.32) | 0.159 | -0.20 (-0.38 to -0.02) | 0.034 |
Non-Hispanic White (N = 124) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCC Metric | Aβ40 | Aβ42 | GFAP | NfL | p-tau181 | Aβ42 / Aβ40 | ||||||
Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | Beta (95% CI)1 | p-value | |
DMLC Total | 0.12 (-0.05 to 0.29) | 0.166 | 0.04 (-0.14 to 0.21) | 0.668 | -0.08 (-0.28 to 0.12) | 0.428 | 0.02 (-0.14 to 0.18) | 0.777 | 0.31 (0.11 to 0.50) | 0.003 | -0.13 (-0.31 to 0.05) | 0.168 |
DMLC Memory | 0.15 (-0.02 to 0.32) | 0.076 | 0.07 (-0.10 to 0.25) | 0.426 | -0.05 (-0.25 to 0.15) | 0.617 | 0.10 (-0.06 to 0.26) | 0.207 | 0.34 (0.14 to 0.54) | < 0.001 | -0.12 (-0.30 to 0.06) | 0.176 |
DMLC Not-Memory | 0.05 (-0.12 to 0.22) | 0.536 | -0.01 (-0.18 to 0.16) | 0.897 | -0.10 (-0.30 to 0.10) | 0.321 | -0.08 (-0.23 to 0.08) | 0.327 | 0.20 (0.00 to 0.40) | 0.05 | -0.10 (-0.28 to 0.07) | 0.253 |
CCI-20 Total | -0.04 (-0.22 to 0.13) | 0.634 | -0.05 (-0.23 to 0.13) | 0.577 | -0.10 (-0.31 to 0.10) | 0.328 | 0.03 (-0.13 to 0.19) | 0.71 | 0.00 (-0.21 to 0.21) | 0.986 | 0.03 (-0.16 to 0.21) | 0.755 |
CCI-20 Memory | -0.04 (-0.21 to 0.13) | 0.64 | -0.05 (-0.23 to 0.13) | 0.576 | -0.13 (-0.33 to 0.08) | 0.22 | 0.04 (-0.12 to 0.20) | 0.658 | -0.02 (-0.23 to 0.19) | 0.832 | 0.03 (-0.16 to 0.21) | 0.772 |
CCI-20 Not Memory | -0.03 (-0.20 to 0.14) | 0.735 | -0.03 (-0.21 to 0.14) | 0.708 | -0.02 (-0.22 to 0.19) | 0.876 | 0.01 (-0.15 to 0.17) | 0.915 | 0.05 (-0.16 to 0.26) | 0.63 | 0.02 (-0.16 to 0.21) | 0.798 |