Table 2 Baseline demographic and clinical characteristics of participants according to the volume of hippocampus and global white matter hyperintensities

Variables

n

%

n

%

OR [95% CI]*

Overall p

n

%

n

%

OR [95% CI]*

Overall p

Sex

< 0.0001

0.58

 Men

237

54.48

64

31.53

1

214

47.03

108

49.32

1

 Women

198

45.52

139

68.47

2.60 [1.83;3.69]

241

52.97

111

50.68

0.91 [0.66;1.26]

Age (years)^a

70.9

(± 4.0)

72.0

(± 4.0)

1.07 [1.02;1.11]

0.002

70.9

(± 3.9)

72.0

(± 4.1)

1.07 [1.03;1.11]

0.0009

Educational level

0.28

0.87

 ≥ Primary

326

74.94

144

70.94

1

336

73.85

163

74.43

1

 < Primary

109

25.06

59

29.06

1.23 [0.84;1.78]

119

26.15

56

25.57

0.97 [0.67;1.40]

APOE ε4 carrier

0.40

0.07

 < 1 allele

349

80.23

157

77.34

1

370

81.32

165

75.34

1

 ≥  1 allele

86

19.77

46

22.66

1.19 [0.79;1.78]

85

18.68

54

24.66

1.42 [0.97;2.10]

Alcohol (g/day)

0.37

0.43

 < 12

251

58.24

123

63.40

1

274

61.16

119

56.40

1

 [12;36[

126

29.23

53

27.32

0.86 [0.58;1.26]

121

27.01

67

31.75

1.27 [0.88;1.84]

 ≥ 36

54

12.53

18

9.28

0.68 [0.38;1.21]

53

11.83

25

11.85

1.09 [0.64;1.83]

History of cardiovascular diseases

0.02

0.05

 No

371

85.48

158

77.83

1

385

84.62

171

78.44

1

 Yes

63

14.52

45

22.17

1.68 [1.10;2.57]

70

15.38

47

21.56

1.51 [1.00;2.28]

Cardiovascular health score ^a

8.3

(± 1.9)

8.3

(± 2.0)

0.99 [0.91;1.08]

0.78

8.5

(± 1.9)

7.9

(± 1.8)

0.86 [0.79;0.94]

0.0007

Depressive status^b

0.003

0.60

 No

327

75.52

129

64.18

1

328

72.57

154

70.64

1

 Yes

106

24.48

72

35.82

1.72 [1.20;2.47]

124

27.43

64

29.36

1.10 [0.77;1.57]

Sleeping pills^c

0.01

0.90

 No

377

86.67

160

78.82

1

384

84.40

184

84.02

1

 Yes

58

13.33

43

21.18

1.75 [1.13;2.70]

71

15.60

35

15.98

1.03 [0.66;1.60]