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Table 3 Association between self-reported sleep parameters and hippocampus volume (n = 638)

From: Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden

 

Hippocampus volume (cm3)

     
 

≥ 5.4

n = 435

< 5.4

n = 203

Model 1

Model 2

Model 3

Model 4

Variables

n

%

n

%

OR [95% CI]

Overall p

OR [95% CI]

Overall p

OR [95% CI]

Overall p

OR [95% CI]

Overall p

Nighttime sleep duration (h)

     

0.23

 

0.20

 

0.21

 

0.21

 ≤ 6

119

29.10

74

38.34

1.33 [0.90;1.98]

 

1.36 [0.91;2.03]

 

1.33 [0.89;2.00]

 

1.35 [0.90;2.01]

 

 ]6;9[

246

60.15

95

49.22

1

 

1

 

1

 

1

 

 ≥ 9

44

10.76

24

12.44

1.47 [0.83;2.60]

 

1.48 [0.83;2.63]

 

1.51 [0.85;2.69]

 

1.49 [0.84;2.65]

 

Napping

     

0.25

 

0.16

 

0.16

 

0.15

 No

213

50.35

122

61.93

1

 

1

 

1

 

1

 

 Infrequent/short

72

17.02

27

13.71

0.87 [0.51;1.46]

 

0.83 [0.49;1.40]

 

0.79 [0.47;1.35]

 

0.81 [0.48;1.38]

 

 Regular long

138

32.62

48

24.37

0.70 [0.46;1.07]

 

0.66 [0.43;1.01]

 

0.67 [0.43;1.02]

 

0.66 [0.43;1.00]

 

Sleep efficiency

     

0.53

 

0.48

 

0.55

 

0.51

 Good (≥ 85%)

206

50.74

85

44.04

1

 

1

 

1

 

1

 

 Poor (< 85%)

200

49.26

108

55.96

1.12 [0.78;1.62]

 

1.14 [0.79;1.65]

 

1.12 [0.77;1.62]

 

1.13 [0.78;1.64]

 

Bedtime

     

0.78

 

0.85

 

0.85

 

0.82

 ≤ 9 pm

22

5.09

12

5.91

1.29 [0.58;2.84]

 

1.19 [0.53;2.67]

 

1.19 [0.53;2.67]

 

1.19 [0.53;2.67]

 

 ]9–11[ pm

166

38.43

76

37.44

1

 

1

 

1

 

1

 

 ≥ 11 pm

244

56.48

115

56.65

1.10 [0.76;1.58]

 

1.10 [0.76;1.58]

 

1.09 [0.75;1.59]

 

1.11 [0.77;1.61]

 

Rising time

     

0.0005*

 

0.0009*

 

0.0005*

 

0.001*

 ≤ 6 am

40

9.26

29

14.29

2.09 [1.21;3.63]

 

2.03 [1.17;3.53]

 

2.04 [1.16;3.56]

 

2.03 [1.17;3.53]

 

 ]6–8] am

336

77.78

131

64.53

1

 

1

 

1

 

1

 

 > 8 am

56

12.96

43

21.18

2.21 [1.38;3.53]

 

2.16 [1.34;3.47]

 

2.29 [1.42;3.69]

 

2.14 [1.33;3.43]

 

Excessive daytime sleepiness, yes

44

10.40

12

6.06

0.78 [0.39;1.55]

0.48

0.76 [0.38;1.50]

0.43

0.75 [0.37;1.49]

0.41

0.76 [0.38;1.51]

0.43

Satisfaction in sleep quality, no

95

22.20

58

29.74

1.26 [0.84;1.88]

0.27

1.29 [0.85;1.94]

0.23

1.23 [0.81;1.86]

0.34

1.25 [0.82;1.89]

0.30

Number of insomnia symptoms

     

0.79

 

0.72

 

0.94

 

0.81

 0

133

31.82

51

26.02

1

 

1

 

1

 

1

 

 1

162

38.76

73

37.24

1.00 [0.64;1.57]

 

1.00 [0.63;1.57]

 

0.99 [0.63;1.57]

 

1.00 [0.63;1.57]

 

 2–3

123

29.43

72

36.73

1.15 [0.72;1.83]

 

1.17 [0.73;1.88]

 

1.07 [0.66;1.75]

 

1.14 [0.70;1.84]

 
  1. Abbreviations CI, confidence interval; OR, odds ratio
  2. Model 1 was adjusted for age, sex, educational level, APOE ε4 carrier, and intracranial volume
  3. Model 2 was adjusted for all the covariates in model 1 plus cardiovascular health and history of cardiovascular diseases
  4. Model 3 was adjusted for all the covariates in model 2 plus depressive status
  5. Model 4 was adjusted for all the covariates in model 2 plus sleeping pills
  6. * Indicates remaining significant even after FDR correction
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Alzheimer's Research & Therapy

ISSN: 1758-9193