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Table 4 Association between self-reported sleep parameters and global white matter hyperintensities volume (n = 674)

From: Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden

White matter hyperintensities volume (cm3)

 

≤ 1.6

n = 455

> 1.6

n = 219

Model 1

Model 2

Model 3

Model 4

Variables

n

%

n

%

OR [95% CI]

Overall p

OR [95% CI]

Overall p

OR [95% CI]

Overall p

OR [95% CI]

Overall p

Nighttime sleep duration (h)

     

0.25

 

0.21

 

0.21

 

0.20

 ≤ 6

129

30.14

72

34.45

1.22 [0.83;1.79]

 

1.23 [0.83;1.81]

 

1.22 [0.82;1.82]

 

1.23 [0.84;1.83]

 

 ]6;9[

247

57.71

120

57.42

1

 

1

 

1

 

1

 

 ≥ 9

52

12.15

17

8.13

0.71 [0.38;1.31]

 

0.69 [0.37;1.28]

 

0.68 [0.36;1.26]

 

0.69 [0.37;1.27]

 

Napping

     

0.47

 

0.43

 

0.47

 

0.44

 No

240

54.05

115

54.25

1

 

1

 

1

 

1

 

 Infrequent/short

79

17.79

28

13.21

0.75 [0.45;1.24]

 

0.72 [0.43;1.20]

 

0.73 [0.43;1.22]

 

0.72 [0.43;1.20]

 

 Regular long

125

28.15

69

32.55

1.03 [0.70;1.52]

 

0.97 [0.66;1.44]

 

0.97 [0.65;1.44]

 

0.98 [0.66;1.45]

 

Sleep efficiency

     

0.88

 

0.80

 

0.79

 

0.78

 Good (≥ 85%)

211

49.65

102

48.80

1

 

1

 

1

 

1

 

 Poor (< 85%)

214

50.35

107

51.20

1.03 [0.73;1.46]

 

1.05 [0.74;1.49]

 

1.05 [0.74;1.50]

 

1.05 [0.74;1.50]

 

Bedtime

     

0.004*

 

0.002*

 

0.002*

 

0.002*

 ≤ 9 pm

19

4.20

17

7.76

1.41 [0.68;2.90]

 

1.27 [0.61;2.66]

 

1.24 [0.59;2.61]

 

1.27 [0.61;2.64]

 

 ]9–11[ pm

155

34.29

98

44.75

1

 

1

 

1

 

1

 

 ≥ 11 pm

278

61.50

104

47.49

0.60 [0.42;0.85]

 

0.57 [0.40;0.81]

 

0.56 [0.39;0.80]

 

0.56 [0.39;0.80]

 

Rising time

     

0.004*

 

0.003*

 

0.001*

 

0.003*

 ≤ 6 am

39

8.61

39

17.89

2.10 [1.27;3.46]

 

2.06 [1.24;3.43]

 

2.16 [1.29;3.61]

 

2.06 [1.24;3.43]

 

 ]6–8] am

336

74.17

153

70.18

1

 

1

 

1

 

1

 

 > 8 am

78

17.22

26

11.93

0.75 [0.45;1.23]

 

0.69 [0.42;1.15]

 

0.64 [0.38;1.08]

 

0.69 [0.42;1.15]

 

Excessive daytime sleepiness, yes

36

8.13

23

10.80

1.62 [0.90;2.90]

0.10

1.57 [0.87;2.83]

0.13

1.56 [0.86;2.81]

0.14

1.57 [0.87;2.83]

0.13

Satisfaction in sleep quality, no

108

24.22

55

25.82

1.13 [0.76;1.67]

0.55

1.13 [0.76;1.69]

0.54

1.18 [0.78;1.78]

0.42

1.14 [0.76;1.71]

0.53

Number of insomnia symptoms

     

0.02

 

0.01*

 

0.01*

 

0.01*

 0

146

33.26

48

22.75

1

 

1

 

1

 

1

 

 1

164

37.36

89

42.18

1.74 [1.13;2.69]

 

1.84 [1.18;2.86]

 

1.85 [1.19;2.88]

 

1.84 [1.18;2.86]

 

 2–3

129

29.38

74

35.07

1.81 [1.14;2.89]

 

1.88 [1.17;3.03]

 

1.96 [1.20;3.18]

 

1.91 [1.18;3.09]

 
  1. Abbreviations CI, confidence interval; OR, odds ratio
  2. Model 1 was adjusted for age, sex, educational level, APOE ε4 carrier, and intracranial volume
  3. Model 2 was adjusted for all the covariates in model 1 plus cardiovascular health and history of cardiovascular diseases
  4. Model 3 was adjusted for all the covariates in model 2 plus depressive status
  5. Model 4 was adjusted for all the covariates in model 2 plus sleeping pills
  6. * Indicates remaining significant even after FDR correction
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Alzheimer's Research & Therapy

ISSN: 1758-9193