Table 6 Association between polysomnography sleep parameters and global white matter hyperintensities volume (n = 176)

≤ 1.6

n = 131

> 1.6

n = 45

Model 1

Model 2

Model 3

Model 4

Variables

median

(Q1-Q3)

median

(Q1-Q3)

OR [95% CI]

Overall p

OR

[95% CI]

Overall p

OR

[95% CI]

Overall p

OR

[95% CI]

Overall p

Nighttime sleep duration (h)

6.1

(5.4–6.9)

6.0

(5.5-7.0)

0.97 [0.70;1.32]

0.83

0.98 [0.71;1.34]

0.89

0.98 [0.71;1.35]

0.92

0.99 [0.72;1.36]

0.93

N1 sleep duration (min) ^a

22.5

(15.0-30.5)

22.0

(11.5–29.5)

1.07 [0.74;1.56]

0.72

1.06 [0.73;1.55]

0.76

1.06 [0.73;1.55]

0.75

1.05 [0.72;1.54]

0.79

% N1 sleep duration ^b

6.0

(4.3–8.4)

6.1

(3.6–9.3)

1.12 [0.72;1.73]

0.61

1.10 [0.70;1.71]

0.68

1.11 [0.71;1.72]

0.70

1.09 [0.70;1.69]

0.72

N2 sleep duration (min) ^c

224.5

(186.5-257.5)

234.5

(210.5-268.5)

1.32 [0.90;1.94]

0.15

1.30 [0.89;1.91]

0.18

1.30 [0.88;1.91]

0.18

1.34 [0.90;1.98]

0.15

% N2 sleep duration ^d

60.8

(55.4–66.6)

65.5

(61.7–69.7)

1.69 [1.11;2.57]

0.02

1.63 [1.06;2.51]

0.03

1.60 [1.04;2.46]

0.03

1.69 [1.09;2.62]

0.02

N3 sleep duration (min) ^e

42.0

(27.5–61.5)

31.0

(21.0-45.5)

0.70 [0.48;1.04]

0.07

0.73 [0.49;1.08]

0.11

0.73 [0.50;1.08]

0.12

0.69 [0.46;1.04]

0.07

% N3 sleep duration ^b

12.0

(7.7–16.9)

9.9

(5.4–13.6)

0.81 [0.61;1.07]

0.14

0.83 [0.62;1.11]

0.20

0.83 [0.62;1.11]

0.21

0.79 [0.58;1.07]

0.13

REM sleep duration (min) ^e

72.5

(57.0–89.0)

67.0

(46.0-81.5)

0.67 [0.46;0.96]

0.03

0.68 [0.47;0.99]

0.05

0.69 [0.47;1.00]

0.05

0.69 [0.48;1.01]

0.05

% REM sleep duration ^b

19.8

(16.0-23.1)

17.1

(13.3–20.6)

0.68 [0.49;0.93]

0.02

0.69 [0.50;0.95]

0.02

0.69 [0.50;0.96]

0.03

0.70 [0.50;0.96]

0.03

SB duration (min) ^g

30.1

(18.8–42.5)

22.5

(14.5–36.0)

0.63 [0.40;0.99]

0.04

0.64 [0.40;1.01]

0.05

0.64 [0.40;1.01]

0.05

0.64 [0.40;1.01]

0.05

NREM SB duration (min) ^b

4.0

(2.5-7.0)

4.0

(3.0-9.5)

1.48 [1.04;2.10]

0.03

1.45 [1.01;2.06]

0.04

1.45 [1.01;2.06]

0.04

1.46 [1.02;2.09]

0.04

REM SB duration (min) ^b

0.0

(0.0-4.5)

0.5

(0.0-2.5)

0.84 [0.60;1.16]

0.29

0.85 [0.61;1.19]

0.36

0.85 [0.61;1.20]

0.36

0.86 [0.61;1.20]

0.37

Sleep efficiency (%) ^d

67.7

(59.9–74.9)

69.6

(61.4–76.4)

1.05 [0.76;1.47]

0.76

1.06 [0.76;1.48]

0.73

1.05 [0.75;1.47]

0.78

1.09 [0.77;1.53]

0.64

Sleep latency (min) ^c

87.0

(66.0-143.5)

84.0

(60.5-118.5)

0.86 [0.58;1.26]

0.44

0.89 [0.60;1.32]

0.55

0.90 [0.61;1.33]

0.59

0.89 [0.60;1.33]

0.57

WASO (min) ^c

174.5

(132.0-226.0)

164.5

(129.0-203.0)

0.88 [0.63;1.24]

0.47

0.88 [0.63;1.23]

0.46

0.89 [0.63;1.25]

0.50

0.85 [0.60;1.21]

0.37

AHI (/h) ^d

3.9

(1.1–11.8)

4.0

(1.6–11.9)

1.01 [0.74;1.39]

0.93

0.98 [0.71;1.35]

0.91

1.00 [0.73;1.37]

0.99

0.97 [0.70;1.34]

0.85

iPLMS ^e

22.1

(8.4–34.3)

29.1

(10.5–50.9)

1.44 [0.98;2.13]

0.06

1.53 [1.03;2.27]

0.04

1.50 [1.01;2.24]

0.046

1.52 [1.02;2.26]

0.04

O2 desaturation index > 3% ^d

6.5

(3.0–17.0)

7.0

(4.0–12.0)

0.92 [0.63;1.34]

0.66

0.90 [0.61;1.33]

0.59

0.91 [0.62;1.34]

0.63

0.89 [0.60;1.32]

0.57