Fig. 3

Sleep-wake profiles of WT and AD mice at 2 months of age. Twenty-four-hour representative hypnogram recording of WT and AD mice at 2 months of age (A). Time course of wakefulness (B), NREM sleep (C), and REM sleep (D) percentages in the WT and AD mice at 2 months of age. Time spent of wakefulness (E), NREM sleep (F), and REM sleep (G) during 24 h, light phase, and dark phase of WT and AD mice at 2 months of age. Average length of wakefulness (H), NREM sleep (I), and REM sleep (J) in WT and AD mice at 2 months of age. Data were the mean ± SEM values, n = 6–8 mice in each group. *p < 0.05, **p < 0.01, by Student’s t-test. EEG power spectrum of NREM sleep (K-L) and REM sleep (M-N) during light phase and dark phase in WT and AD mice at 2 months of age