Fig. 4

Sleep-wake profiles of WT and AD mice at 10 months of age. 24-hour representative hypnogram recording of WT and AD mice at 10 months of age (A). Time course of wakefulness (B), NREM sleep (C), and REM sleep (D) percentages in the WT and AD mice at 10 months of age. Time spent of wakefulness (E), NREM sleep (F), and REM sleep (G) during 24 h, light phase, and dark phase of WT and AD mice at 10 months of age. Average length of wakefulness (H), NREM sleep (I), and REM sleep (J) in the WT and AD mice at 10 months of age. Data were the mean ± SEM values, n = 7–8 mice in each group. *p < 0.05, **p < 0.01, by Student’s t-test. EEG power spectrum of NREM sleep (K-L) and REM sleep (M-N) during light phase and dark phase in the WT and AD mice at 10 months of age