Fig. 6

Clock gene expression rhythms in the hippocampus of WT and AD mice. The mRNA levels of clock genes (Clock, Bmal1, Dec1, Dec2, Cry1, Cry2, Rora, Rorb, Per1, Per2, Dbp, Nr1d1) in the hippocampus of WT and AD mice at 2 months of age (A). The mRNA levels of clock genes (Clock, Bmal1, Dec1, Dec2, Cry1, Cry2, Rora, Rorb, Per1, Per2, Dbp, Nr1d1) in the hippocampus of WT and AD mice at 10 months of age (B). The white box indicates the light phase, while the gray box indicates the dark phase. The asterisks indicate significant differences between WT and AD mice at each time point. Data were presented as mean ± SEM and analyzed by using Student’s t-test, n = 4 mice in each group, *P<0.05, **P<0.01, ***P<0.001